Stabilization of Aerosolizable Nano-carriers by Freeze-Drying
| Autor: | Johannes Sitterberg, Claudia B. Packhaeuser, Udo Bakowsky, Tobias Gessler, Thomas Schmehl, Werner Seeger, Kerstin Lahnstein, Thomas Kissel |
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| Rok vydání: | 2008 |
| Předmět: |
Materials science
Polymers Pharmacology toxicology Pharmaceutical Science Nanotechnology Microscopy Atomic Force Arsenicals Excipients Freeze-drying Polylactic Acid-Polyglycolic Acid Copolymer Suspensions Electrochemistry Laser-Doppler Flowmetry Pharmacology (medical) Lactic Acid Particle Size Polyglactin 910 Aerosolization Aerosols Pharmacology Polylactic acid-polyglycolic acid copolymer Drug Carriers Viscosity Nano carriers Nebulizers and Vaporizers Organic Chemistry technology industry and agriculture Freeze Drying Polyvinyl Alcohol Nanoparticles Molecular Medicine Polyglycolic Acid Biotechnology |
| Zdroj: | Pharmaceutical Research. 26:129-138 |
| ISSN: | 1573-904X 0724-8741 |
| Popis: | This study investigates the feasibility of freeze-drying aerosolizable nano-carriers (NC) by the use of different lyoprotective agents (LPA) and the influence of the freeze-drying on the physicochemical properties of these nano-carriers and on their aerosolization.Nano-carriers were prepared from fast-degrading polymers, DMAPA(24)-PVAL-g-PLGA(1:7.5) and DEAPA(26)-PVAL-g-PLGA(1:10), and freeze-dried using increasing concentrations of different LPA. The hydrodynamic diameter, zeta potential and morphology (atomic force microscopy) of NC were characterized before and after freeze-drying. The ability to aerosolize using a jet nebulizer and an electronic micro-pump nebulizer was also investigated.Freeze-drying with LPA led to a decreased zeta-potential of NC and changes in size about 20 nm without alteration in shape, whereas lyophilizates without LPA were found to aggregate. While freeze-drying was positively affected by increasing concentrations, it was not influenced by the type of LPA. The possibility for aerosolization was not influenced by any LPA.Freeze-drying with LPA is a suitable method to physically stabilize fast-degrading NC from aqueous suspensions without influencing the aerosolizability. |
| Databáze: | OpenAIRE |
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