Efficacy of a skeletal muscle—powered dynamic patch: Part 1. Left ventricular assistance
| Autor: | Masao Takahashi, Masanari Wada, Takuro Misaki, Yoshio Tsunezuka, Michio Kawasuji, Hiroshi Ohtake, Yasuhiro Matsunaga, Naoki Sakakibara, Yoh Watanabe, Go Watanabe |
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| Rok vydání: | 1995 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_treatment Blood Pressure Ventricular Function Left law.invention Electrocardiography Dogs Heart Rate law medicine.artery Pressure medicine Cardiopulmonary bypass Animals Cardiomyoplasty Aorta business.industry Latissimus dorsi muscle Mean Aortic Pressure Skeletal muscle Atrial Function medicine.anatomical_structure Blood pressure Regional Blood Flow Anesthesia cardiovascular system Aortic pressure Surgery Heart-Assist Devices Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Annals of Thoracic Surgery. 59:305-312 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/0003-4975(94)00528-f |
| Popis: | In this study, we examined the capability of a skeletal muscle-powered, dynamic patch to provide left ventricular assistance. An actuator was developed that used linear traction power furnished by the latissimus dorsi muscle and liquid as the medium for power transfer. The proximal portion of the muscle was dissected and was reattached to the actuator. The left ventricular apex was excised, and the dynamic patch lined with autologous pericardium was implanted during cardiopulmonary bypass. Hemodynamic studies were performed in 8 dogs after weaning from cardiopulmonary bypass. Muscle stimulation was found to significantly increase the systolic aortic pressure (91.6 versus 112.1 mm Hg; p < 0.01), the mean aortic pressure (65.2 versus 73.0 mm Hg; p < 0.01), and aortic blood flow (0.77 versus 0.92 L/min; p < 0.01). The left atrial pressure decreased from 17.9 to 16.6 mm Hg (p < 0.01). This "hybrid" left ventricular assist device possesses notable clinical advantages because of its remarkable efficacy in assisting circulation. Further experimental studies using preconditioned skeletal muscle are necessary to assess the long-term effects of this technique. |
| Databáze: | OpenAIRE |
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