Combined Sarcoidosis and Idiopathic Pulmonary Fibrosis (CSIPF): A New Phenotype or a Fortuitous Overlap? Scoping Review and Case Series

Autor:	Laura Bergantini, Gabriele Nardelli, Miriana d’Alessandro, Giusy Montuori, Caterina Piccioli, Elisabetta Rosi, Sara Gangi, Dalila Cavallaro, Paolo Cameli, Elena Bargagli
Rok vydání:	2022
Předmět:	CSIPF lone-IPF fibrotic sarcoidosis scoping review General Medicine respiratory system respiratory tract diseases
Zdroj:	Journal of clinical medicine. 11(7)
ISSN:	2077-0383
Popis:	Idiopathic pulmonary fibrosis (IPF) and sarcoidosis are two distinct clinical entities with different aetiology, epidemiology, risk factors, symptoms and chest imaging. A number of papers have reported an overlap of the two diseases and have suggested the existence of a distinct phenotype defined as combined sarcoidosis and idiopathic pulmonary fibrosis (CSIPF). We used the scoping review protocol to review the literature on CSIPF. We also enrolled a cohort of nine CSIPF patients and compared them with lone-IPF and fibrotic sarcoidosis patients. Our CSIPF cohort showed male prevalence and only ex-smokers. Functional assessment at baseline showed mild to moderate restrictive impairment of lung volumes in lone-IPF and CSIPF patients, associated with moderate-to-severe reduction in DLco percentages. Although all CSIPF patients were on antifibrotic treatments, functional impairment occurred in the two years of follow up. This suggests the importance of considering these patients at high risk of rapid deterioration and lung damage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa775a649c1abc313bedd24c02a4a1e https://pubmed.ncbi.nlm.nih.gov/35407673 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.