Chronic Cadmium Exposure Attenuates Ethanol-Induced Hypoalgesia in the Adult Rat
| Autor: | Jack R. Nation, Robert T. Burkey, Cathy A. Grover, Gerald D. Bratton |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Pain Threshold Cadmium Poisoning medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) chemistry.chemical_element Toxicology Acclimatization Cadmium poisoning Hypesthesia Rats Sprague-Dawley chemistry.chemical_compound Internal medicine Threshold of pain Reaction Time medicine Animals Thermosensing Saline Cadmium Ethanol Hypoalgesia Dose-Response Relationship Drug Nociceptors Biological activity medicine.disease Rats Psychiatry and Mental health Endocrinology chemistry Anesthesia |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 17:423-427 |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/j.1530-0277.1993.tb00787.x |
| Popis: | Adult male rats were exposed to a diet containing either 100 ppm added cadmium (Cadmium-Diet), or a control diet containing no added chemicals (Control-Diet) for 67 days prior to pain reactivity testing using a tail-flick procedure. Rats were placed in restraining tubes for a 20-min acclimation period, then baseline tail-flick latencies in response to a radiant heat source were measured. Subsequently, half the animals from each group were serially injected intraperitoneally with either 0.5, 1.0, 1.5, or 2.0 g/kg body weight of a 20% v/v ethanol solution, and the other half of the animals were injected with an equivalent volume of saline. Tail-flick latencies were reassessed at 20-min intervals over the next 2 hr. Results indicated dose-dependent ethanol-induced hypoalgesia in the Control-Diet animals for the two highest doses, but ethanol-induced hypoalgesia was evident only at the highest dose for the Cadmium-Diet animals. Further, the magnitude of this hypoalgesic effect was significantly lower for the Cadmium-Diet animals than the Control-Diet animals at the 2.0 g/kg dose. Results are discussed in terms of an attenuation of the pharmacological properties of ethanol by cadmium. |
| Databáze: | OpenAIRE |
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