Correlation between the Banff 97 classification of renal allograft biopsies and clinical outcome

Autor: Koji Yazawa, Kiyohide Toki, Toshiki Moriyama, Masahiro Kyo, Naotsugu Ichimaru, Hidetoshi Yamanaka, Akihiko Okuyama, Enyu Imai, Kazuhiro Suzuki, Masaru Hasumi, Motoaki Hatori, Yukito Kokado, Shiro Takahara, Kazumasa Oka, Toru Hanafusa, Toshiyuki Tanaka, Yukiomi Namba
Rok vydání: 2004
Předmět:
Zdroj: Transplant International. 17:59-64
ISSN: 1432-2277
0934-0874
DOI: 10.1111/j.1432-2277.2004.tb00405.x
Popis: The 1997 fourth Banff meeting revised the consensus for describing transplant biopsies. We have conducted a retrospective analysis of biopsies correlated between the Banff 97 classification and clinical outcome. The patients ( n=149), who had a total of 404 biopsy-proven rejections, were assessed and the biopsies taken from these patients were re-examined and classified according to the Banff 97 classification. Morphological changes in the glomeruli (g), interstitium (i), tubules(t), and arterial vessels (v) were scored. Severity of acute rejection was statistically associated with unresponsiveness to anti-rejection treatment ( P0.0001) and predicted an increased risk of graft failure ( P0.05). Each quantitative criterion (g, i, t, and v) was also statistically associated with unresponsiveness to anti-rejection treatment. Mean serum creatinine levels were significantly higher in the groups graded Banff 97 type I-III after 1 and 2 years of follow-up. The Banff 97 classification correlated with reversibility of rejection episodes and long-term graft survival.
Databáze: OpenAIRE
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