Neutrophil-to-Lymphocyte Ratio and Traumatic Brain Injury: A Review Study
| Autor: | Sepideh Rahigh Aghsan, Puria Jangjui, Elham Sabouri, Alireza Majdi, Seyed Ahmad Naseri Alavi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Traumatic brain injury Neutrophils 03 medical and health sciences 0302 clinical medicine Outcome predictor Internal medicine Brain Injuries Traumatic medicine Humans In patient Lymphocytes Neutrophil to lymphocyte ratio Review study business.industry Mortality rate fungi Glasgow Coma Scale medicine.disease Prognosis nervous system diseases Survival Rate nervous system 030220 oncology & carcinogenesis Surgery Neurology (clinical) Cerebral tissue business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | World neurosurgery. 140 |
| ISSN: | 1878-8769 |
| Popis: | Traumatic brain injury (TBI) is the leading cause of morbidity and mortality worldwide. Several prognostic factors have been developed to predict functional outcomes and mortality rate in patients with TBI. Neutrophil-to-lymphocyte ratio (NLR) is an objective, available, low-cost, and reproducible indicator of inflammation. It is also a marker of extensive secondary damage caused by neutrophils and their products to the cerebral tissue. Accordingly, NLR has been proposed as a valuable outcome predictor in patients with TBI. Evidence emerging from several studies shows that higher NLR value is an independent predictor of poorer functional outcomes and higher mortality rate in patients with severe TBI. Further, higher NLR value is in correlation with lower Glasgow Coma Scale scores. Thus its role as a complementary index to other factors, such as Glasgow Coma Scale, in predicting outcomes after TBI is under investigation. This review aims at gathering the most recent data on the prognostic value of NLR in patients with TBI. |
| Databáze: | OpenAIRE |
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