Comparative pharmacokinetics of three phenylpropanoids in rat plasma after oral administration of Ramulus Cinnamomi and Ramulus Cinnamomi-Ephedrae Herba herb-couple extract
| Autor: | Ping Wei, Xuefeng Xing, Qingfa Tang, Shuai Song, Hui-ling Huo, Jiabo Luo, Fei-Long Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
food.ingredient
010401 analytical chemistry Area under the curve General Medicine Absorption (skin) Pharmacology Ephedrae Herba Coumarin 030226 pharmacology & pharmacy 01 natural sciences Cinnamic acid 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food Complementary and alternative medicine chemistry Pharmacokinetics Oral administration Herb Pharmacology (medical) |
| Zdroj: | Chinese Journal of Integrative Medicine. |
| ISSN: | 1993-0402 1672-0415 |
| DOI: | 10.1007/s11655-017-2799-8 |
| Popis: | To investigate the pharmacokinetic characteristics of three phenylpropanoids (cinnamic acid, cinnamic alcohol and coumarin) in Ramulus Cinnamomi (GZ) and Ramulus Cinnamomi-Ephedrae Herba (MH) herb-couple (GZMH).Twelve male Sprague-Dawley rats were randomly and equally divided into the GZ and GZMH herb-couple groups. Blood samples were collected at 0, 0.08, 0.25, 0.5, 0.75, 1.5, 3, 4, 6, 8, 12, 24, 36 and 48 h after oral administration. The three phenylpropanoids in rat plasma were quantified using an ultra-performance liquid-chromatography with tandem mass spectrometry (UPLC-MS/MS) method for pharmacokinetic study.In GZMH group, the area under the curve (AUC), mean retention time (MRT) of cinnamic acid and coumarin were increased significantly (P0.01, respectively), and biological half-life (tThere were statistically significant differences in some pharmacokinetic parameters of the three compounds between GZ and GZMH groups, which meant that MH could affect the absorption and elimination of the three compounds. |
| Databáze: | OpenAIRE |
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