Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren's syndrome
| Autor: | Peter Ruoff, Ingeborg Kvivik, Anne Bolette Tjensvoll, Roald Omdal, Cato Brede, Kjetil Bårdsen, Kristin Jonsdottir, Jan Terje Kvaløy |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Neurology medicine.drug_class Visual analogue scale Hypocretin Immunology lcsh:RC346-429 Cohort Studies 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cerebrospinal fluid Medisinske Fag: 700 [VDP] Internal medicine medicine Humans Fatigue lcsh:Neurology. Diseases of the nervous system Depression (differential diagnoses) Aged Innate immunity Orexins business.industry Research General Neuroscience Interleukin Radioimmunoassay Middle Aged Receptor antagonist Sjogren's Syndrome 030104 developmental biology Endocrinology Sjögren’s syndrome Cytokines Female Wakefulness business Biomarkers 030217 neurology & neurosurgery Interleukin-1 |
| Zdroj: | Journal of Neuroinflammation Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-9 (2019) |
| Popis: | Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide hypocretin-1 (Hcrt1), a regulator of wakefulness, influence fatigue. Methods Hcrt1 was measured by radioimmunoassay (RIA) in cerebrospinal fluid (CSF) from 49 patients with pSS. Interleukin-1 receptor antagonist (IL-1Ra), IL-1 receptor type 2 (IL-1RII), IL-6, and S100B protein were measured by enzyme-linked immunosorbent assay (ELISA). Fatigue was rated by the fatigue visual analog scale (fVAS). Results Simple univariate regression and multiple regression analyses with fatigue as a dependent variable revealed that depression, pain, and the biochemical variable IL-1Ra had a significant association with fatigue. In PCA, two significant components were revealed. The first component (PC1) was dominated by variables related to IL-1β activity (IL-1Ra, IL-1RII, and S100B). PC2 showed a negative association between IL-6 and Hcrt1. fVAS was then introduced as an additional variable. This new model demonstrated that fatigue had a higher association with the IL-1β-related PC1 than to PC2. Additionally, a third component (PC3) became significant between low Hcrt1 concentrations and fVAS scores. Conclusions The main findings of this study indicate a functional network in which several IL-1β-related molecules in CSF influence fatigue in addition to the classical clinical factors of depression and pain. The neuropeptide Hcrt1 seems to participate in fatigue generation, but likely not through the IL-1 pathway. Electronic supplementary material The online version of this article (10.1186/s12974-019-1502-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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