MR imaging of cerebral lesions accompanying stroke in stroke-prone spontaneously hypertensive rats

Autor:	M, Takahashi, B, Fritz-Zieroth, M, Yamaguchi, H, Ogawa, T, Tanaka, S, Sasagawa, T, Chikugo, Y, Ohta, K, Okamoto
Rok vydání:	1992
Předmět:	Male Pharmacology Aging Cerebrovascular Disorders Behavior Animal Rats Inbred SHR Body Weight Hypertension Animals Brain Blood Pressure Magnetic Resonance Imaging Rats
Zdroj:	Folia Pharmacologica Japonica. 100:21-28
ISSN:	1347-8397 0015-5691
DOI:	10.1254/fpj.100.21
Popis:	Cerebral lesions accompanying stroke in male stroke-prone spontaneously hypertensive rats (SHRSP, n = 10) were examined by both magnetic resonance imaging (MRI) and histological evaluation. T2-weighted MR images (T2-WI), taken 1-2 days after animals showed behavioral hyperactivity, indicated hyperintense regions in the occipital cortex, caudate putamen and/or thalamus. The areas of hyperintensity on T2-WI corresponded to neurodegenerative regions including edema, gliosis, and softening of the tissue. T1-weighted images (T1-WI) did not show any hyperintense regions. However T1-weighted images enhanced by the contrast media Gd-DTPA (Gd-T 1-WI) showed hyperintense spots within some of the hyperintense areas on T2-WI, which exhibited neurodegenerative regions such as thrombus, angionecrosis and hemorrhage in addition to the edematous formation. The hyperintense areas on Gd-T1-WI were smaller than those on T2-WI. In some animals, hypointense spots on T2-, T1- and Gd-T1-WI were found within the hyperintense areas, which corresponded to clots. Extensive histological examination did not reveal any additional cerebral degeneration which had not been detected on the MR images. These findings indicate that MRI is useful for detecting and differentiating various types of cerebrovascular disease in this model.
Databáze:	OpenAIRE
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