Diastereomeric 7-.ALPHA.-ureidoacetyl cephalosporins. V. Antimicrobial activity, .BETA.-lactamase stability and pharmacokinetics of 7-(.ALPHA.-ureido-2-amino-4-thiazolylacetyl)-cephalosporins
| Autor: | B. Starke, I. Polacek |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.drug_class
Stereochemistry medicine.medical_treatment Cephalosporin Alpha (ethology) Urine beta-Lactamases Mice Drug Stability Pharmacokinetics Drug Discovery medicine Animals Cephalosporinase Pharmacology Bacteria biology Chemistry Diastereomer Bacterial Infections Antimicrobial biology.organism_classification Cephalosporins Kinetics Beta-lactamase |
| Zdroj: | The Journal of Antibiotics. 33:1031-1036 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.33.1031 |
| Popis: | Diastereomeric 7-(alpha-ureido-2-amino-4-thiazolylacetyl)cephalosporins are broad-spectrum antimicrobial agents with activity mainly against Gram-negative bacteria. The L-isomers were more potent than the D-isomers. All compounds showed some degree of stability to beta-lactamases. The compounds reached high serum and tissue fluid levels and were excreted unchanged mainly in urine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|