Renal crystal-storing histiocytosis involving glomeruli - A comprehensive clinicopathologic analysis
| Autor: | Avi Z. Rosenberg, Lois J. Arend, Rajib K. Gupta, Serena M. Bagnasco |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Biopsy Plasma cell dyscrasia Paraproteinemias urologic and male genital diseases Kidney Glomerulonephritis Membranous Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Histiocyte Multiple myeloma Aged Creatinine medicine.diagnostic_test urogenital system business.industry Glomerular mesangium Histiocytes General Medicine Middle Aged medicine.disease Lymphoproliferative Disorders Glomerular Mesangium Histiocytosis Microscopy Electron Proteinuria 030104 developmental biology medicine.anatomical_structure Myeloma Proteins chemistry 030220 oncology & carcinogenesis Myelodysplastic Syndromes Female business Multiple Myeloma |
| Zdroj: | Annals of diagnostic pathology. 43 |
| ISSN: | 1532-8198 |
| Popis: | Crystal-storing histiocytosis (CSH) is a rare manifestation of monoclonal gammopathy in which histiocytes containing monoclonal proteins in their cytoplasm are found in various organs of the body including the kidney. Within the kidney, these monoclonal crystal-laden histiocytes have been described to occur in the interstitium (most commonly) or in the glomerular mesangium. CSH within glomerular capillary loops has rarely been reported. We describe three cases of CSH primarily affecting the glomerular capillaries and review the literature of CSH in general. Twenty cases of CSH involving the kidney are present in the literature; three describe CSH in glomeruli, only one of which showed histiocytes predominantly in glomerular capillary loops, while 15 had predominantly or solely interstitial CSH. Most cases involve IgG kappa crystals with only one case involving lambda light chain. Patients with CSH predominantly involving the glomerular capillaries showed a trend toward lower serum creatinine and proteinuria at presentation, and several patients with CSH lacked a definitive diagnosis of a monoclonal gammopathy at the time of diagnosis, emphasizing the role that kidney biopsy and particularly electron microscopy play in diagnosis of this entity. |
| Databáze: | OpenAIRE |
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