Lack of association between CTLA-4 and PDCD1 polymorphisms and acute rejection in German liver transplant recipients
| Autor: | Hansjörg Thude, Martina Sterneck, Anna Dorothea Schipler, Andras Treszl, Björn Nashan, Sven Peine, Martina Koch |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Graft Rejection Male Candidate gene Genotype medicine.medical_treatment Hepatitis C virus Programmed Cell Death 1 Receptor Immunology Single-nucleotide polymorphism Azathioprine Liver transplantation Biology medicine.disease_cause Polymorphism Single Nucleotide White People Gene Frequency Germany Odds Ratio medicine Humans Immunology and Allergy CTLA-4 Antigen Allele Alleles Aged Retrospective Studies General Medicine Middle Aged medicine.disease Liver Transplantation Transplant rejection Tolerance induction Female medicine.drug |
| Zdroj: | Human Immunology. 74:1041-1045 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2013.04.021 |
| Popis: | Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell-death 1 (PDCD1) are two genes encoding coinhibitory immunoreceptors that are involved in regulation transplant rejection and tolerance induction. Thus, CTLA-4 and PDCD1 may be good candidate genes to evaluate in liver transplant rejection. In this retrospective study, we investigated whether four functional single nucleotide polymorphisms (SNP) of the CTLA-4 gene and PDCD1 gene were associated with susceptibility to liver transplant rejection. The SNPs -1772T>C (rs733618), -1661A>G (rs4553808) of the CTLA-4 gene, and the SNPs 7146G>A (rs11568821), 7209C>T (rs41386349) of the PDCD1 gene were genotyped by polymerase chain reaction allele specific restriction enzyme analysis (PCR-ASRA) in 100 liver recipients with acute rejection, 104 liver transplant recipients without acute rejection and 100 healthy control individuals. For the selected SNPs we did not detect any significant difference in genotypic and allelic frequencies between liver transplant recipients with and without acute rejection. In conclusion, our results suggest that the tested SNPs may not be associated with susceptibility to acute liver transplant rejection in a Caucasian population. |
| Databáze: | OpenAIRE |
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