Status of some free radical scavenging enzymes in the blood of myocardial infarction patients

Autor:	Prakash C. Misra, M. Chandra, Aparna Misra, M. K. Misra, V K Dwivedi
Rok vydání:	2006
Předmět:	Male medicine.medical_specialty Free Radicals Glutathione reductase Myocardial Infarction Myocardial Reperfusion Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Malondialdehyde Internal medicine Drug Discovery medicine Humans Myocardial infarction Aged Pharmacology chemistry.chemical_classification biology Superoxide Dismutase business.industry Free Radical Scavengers General Medicine Myocardial Disorder Middle Aged Catalase medicine.disease Surgery Glutathione Reductase Endocrinology Enzyme chemistry biology.protein Lipid Peroxidation business
Zdroj:	Journal of Enzyme Inhibition and Medicinal Chemistry. 21:43-46
ISSN:	1475-6374 1475-6366
DOI:	10.1080/14756360500286070
Popis:	Pro-oxidant and anti-oxidant systems and their levels have significant roles in occlusive vascular diseases. In the present communication, we have measured the levels of some representative anti-oxidant enzymes in the blood of the patients of myocardial infarction after reperfusion and compared them to age and sex matched healthy persons. Our findings show that the activities of anti-oxidant enzymes (viz. SOD, catalase and glutathione reductase) are significantly decreased whereas there is significant increase in the levels of malonaldialdehyde (a marker of free radical-mediated damage) in the patients. The findings point out that ischemic myocardial disorders are associated with excessive free radical generation and free radical-mediated damage of lipids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9e78515c2b9e7c8cdb799b0825aaca https://doi.org/10.1080/14756360500286070 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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