A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
Autor: | Joseph Batta-Mpouma, Zachary Heidrick, Yuchun Du, Miu Tsuji, Hudson Beyzavi, John Ozdemir, Arvind Sinha, Jin-Woo Kim, Christopher Salmon, Yoshie Sakamaki, Olivia Watson, Anthony Azzun, Zachary McConnell, David Fugitt |
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Rok vydání: | 2021 |
Předmět: |
Porphyrins
medicine.medical_treatment Biomedical Engineering Antineoplastic Agents Triple Negative Breast Neoplasms Photodynamic therapy Article Biomaterials chemistry.chemical_compound Drug Delivery Systems Photosensitivity Cell Line Tumor Pancreatic cancer Organometallic Compounds polycyclic compounds medicine Humans Photosensitizer Triple-negative breast cancer Molecular Structure fungi Biochemistry (medical) General Chemistry medicine.disease Porphyrin Nanostructures Pancreatic Neoplasms Photochemotherapy chemistry Chlorin Cancer cell Cancer research |
Zdroj: | ACS Appl Bio Mater |
ISSN: | 2576-6422 |
Popis: | The field of photodynamic therapy (PDT) has continued to show promise as a potential method for treating tumors. In this work a photosensitizer (PS) has been delivered to cancer cell lines for PDT by incorporation into the metal-organic framework (MOF) as an organic linker. By functionalizing the surface of MOF nanoparticles with maltotriose the PS can efficiently target cancer cells with preferential uptake into pancreatic and breast cancer cell lines. Effective targeting overcomes some current problems with PDT including long-term photosensitivity and tumor specificity. Developing a PS with optimal absorption and stability is one of the foremost challenges in PDT and the synthesis of a chlorin which is activated by long-wavelength light and is resistant to photo-bleaching is described. This chlorin-based MOF shows anti-cancer ability several times higher than that of porphyrin-based MOFs with little toxicity to normal cell lines and no dark toxicity. |
Databáze: | OpenAIRE |
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