Cardiovascular Manifestations of Substance Abuse
| Autor: | Shirin Sanal, Anjum Ismail, Alexander Del Vecchio, William H. Frishman |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Heart Diseases medicine.drug_class Cardiomyopathy Left ventricular hypertrophy Sudden death Muscle Smooth Vascular Cocaine-Related Disorders Cocaine Dopamine Uptake Inhibitors Nifedipine Heart Conduction System Internal medicine medicine Animals Humans Vasoconstrictor Agents cardiovascular diseases Myocardial infarction Tachyphylaxis Psychiatry Molecular Structure business.industry Local anesthetic medicine.disease Substance abuse Coronary vasospasm Cardiology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Heart Disease. 5:187-201 |
| ISSN: | 1521-737X |
| DOI: | 10.1097/01.hdx.0000074519.43281.fa |
| Popis: | Substance abuse with cocaine is associated with multiple cardiovascular conditions, including myocardial infarction, dissection, left ventricular hypertrophy, arrhythmias, sudden death, and cardiomyopathy. Cocaine has effects to potentiate the physiologic actions of catecholamines and has direct effects on voltage-dependent sodium ion channels related to local anesthetic properties. The effects of cocaine can be augmented with concomitant alcohol consumption. Acute myocardial ischemia caused by cocaine may be related to in situ thromboisis and/or coronary vasospasm. Treatment strategies for cocaine-induced myocardial infarction would include antiplatelet therapy, thrombolysis, and vasodilators (eg, nitrates, nifedipine). Beta-adrenergic blockers should not be used unless concomitant vasodilator therapy is given. |
| Databáze: | OpenAIRE |
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