Are micronutrient levels and supplements causally associated with the risk of Alzheimer's disease? A two-sample Mendelian randomization analysis

Autor:	Lei Meng, Zhe Wang, Yu-Cheng Ming, Liang Shen, Hong-Fang Ji
Rok vydání:	2022
Předmět:	Selenium Alzheimer Disease Humans Micronutrients Vitamins General Medicine Mendelian Randomization Analysis Vitamin D Vitamin A Copper Genome-Wide Association Study Food Science
Zdroj:	Food & Function. 13:6665-6673
ISSN:	2042-650X 2042-6496
DOI:	10.1039/d1fo03574f
Popis:	The potential of micronutrients, including vitamins and minerals, to prevent Alzheimer's disease (AD) has attracted much attention. However, the causal associations between micronutrient levels or supplements and AD risk remain unclear. We performed a two-sample Mendelian randomization (2SMR) analysis to evaluate the causal associations between micronutrient levels and supplements and AD risk. A total of 60 genome-wide association studies (GWAS) related to five types of vitamins (vitamins A, B, C, D, and E) and seven types of minerals (magnesium, calcium, iron, copper, zinc, selenium, and phosphorus) were included. For vitamins, using the data source provided by two GWAS, the analysis of 2SMR indicated that the vitamin D level was causally associated with a decreased risk of AD (IVW, OR: 0.474, 95%CI: 0.269-0.834
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a99d388a2a4cba42abb41d6c4010aa4 https://doi.org/10.1039/d1fo03574f Zobrazit plný text záznamu