Serum adiponectin in chronic hepatitis C and B
| Autor: | Athanassios C. Tsamandas, G. Vafiadis, M. Michalaki, Ioannis Starakis, M. Makri, Alexandra Lekkou, Chryssoula Labropoulou-Karatza, V. Margaritis, Myrto Christofidou, D. Siagris |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Hepatitis B virus Hepatitis C virus medicine.medical_treatment Biopsy Hepacivirus medicine.disease_cause Chronic liver disease Gastroenterology Insulin resistance Hepatitis B Chronic Virology Internal medicine medicine Humans Aspartate Aminotransferases Triglycerides Hepatology Adiponectin business.industry Histocytochemistry Insulin Globulins Hepatitis C gamma-Glutamyltransferase Hepatitis B Hepatitis C Chronic Middle Aged medicine.disease Alkaline Phosphatase Infectious Diseases C-Reactive Protein Cholesterol Immunology DNA Viral RNA Viral Female Insulin Resistance business |
| Zdroj: | Journal of viral hepatitis. 14(8) |
| ISSN: | 1352-0504 |
| Popis: | Adiponectin possesses anti-inflammatory, insulin-sensitizing and anti-atherosclerotic properties. The aim of this study was to assess the levels of serum adiponectin in patients with chronic viral hepatitis C and B and correlate them with parameters exploring insulin resistance and indices of chronic liver disease. Seventy-two patients with chronic hepatitis C virus (HCV) infection and 73 patients with chronic hepatitis B virus (HBV) infection, matched for age and sex, were studied. All individuals were examined for serum concentrations of adiponectin, insulin, C-peptide and homeostasis model assessment for insulin resistance (HOMA-IR). Viral parameters and liver histology were also evaluated. Serum adiponectin levels were significantly higher in HCV compared with HBV-infected patients. Correlation analysis in the whole group demonstrated that serum adiponectin was positively correlated with aspartate aminotransferase, alkaline phosphatase, globulins, high-density lipoprotein cholesterol and staging score, while it was negatively correlated with body mass index, insulin, C-peptide and HOMA-IR. Logistic regression analysis identified type of infection (HCV vs HBV), alcohol consumption more than 25 g daily, serum total globulin and low C-peptide as significant predictive variables associated with high adiponectin levels. Higher levels of serum adiponectin in HCV compared with HBV patients could have a role in the slower disease progression of chronic HCV infection. In addition, alcohol intake more than 25 g daily seems to be a significant predictor for hyperadiponectinaemia in patients with chronic viral hepatitis C or B. Finally, in this study, a clear positive association between adiponectin and hepatic necroinflammation or staging score was not found. |
| Databáze: | OpenAIRE |
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