Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity
| Autor: | Pilaipan Puthavathana, Tobias Silberzahn, Oliver Planz, Igor Mazur, Walter J. Wurzer, Stephan Ludwig, Christina Ehrhardt, Thorsten Wolff, Stephan Pleschka |
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| Rok vydání: | 2007 |
| Předmět: |
Drug
media_common.quotation_subject Immunology Influenza A Virus H7N7 Subtype IκB kinase Biology Pharmacology Virus Replication Microbiology Antiviral Agents Virus Cell Line Mice Influenza A Virus H1N1 Subtype Orthomyxoviridae Infections In vivo Virology medicine Animals Humans Nuclear export signal media_common Aspirin Influenza A Virus H5N1 Subtype NF-kappa B In vitro Mice Inbred C57BL Viral replication medicine.drug |
| Zdroj: | Cellular microbiology. 9(7) |
| ISSN: | 1462-5814 |
| Popis: | Summary Influenza is still one of the major plagues worldwide. The statistical likeliness of a new pandemic outbreak highlights the urgent need for new and amply avail- able antiviral drugs. We and others have shown that influenza virus misuses the cellular IKK/NF-kB signal- ling pathway for efficient replication suggesting that this module may be a suitable target for antiviral inter- vention. Here we examined acetylsalicylic acid (ASA), also known as aspirin, a widely used drug with a well-known capacity to inhibit NF-kB. We show that the drug efficiently blocks influenza virus replication in vitro and in vivo in a mechanism involving impaired expression of proapoptotic factors, subsequent inhi- bition of caspase activation as well as block of caspase-mediated nuclear export of viral ribonucle- oproteins. As ASA showed no toxic side-effects or the tendency to induce resistant virus variants, existing salicylate-based aerosolic drugs may be suitable as anti-influenza agents. This is the first demonstration that specific targeting of a cellular factor is a suitable approach for anti-influenza virus intervention. |
| Databáze: | OpenAIRE |
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