Role of Adult-Born Versus Preexisting Neurons Born at P0 in Olfactory Perception in a Complex Olfactory Environment in Mice
| Autor: | Claire Benetollo, Isabelle Caillé, Joëlle Sacquet, Jeremy Forest, Laura Chalençon, Killian Martin, Nathalie Mandairon, Maellie Midroit, Marion Richard, Claire Terrier, Anne Didier |
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| Přispěvatelé: | Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neurosciences Paris Seine (NPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Sorbonne Paris Cité (USPC), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7), Neurosciences Sensorielles Comportement Cognition, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire de psychologie : dynamiques relationnelles et processus identitaires [Dijon] (PSY-DREPI), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut Technique de la Betterave (ITB), Confédération Générale des Planteurs de Betteraves, Neuroscience Paris Seine (NPS), Gestionnaire, Hal Sorbonne Université |
| Rok vydání: | 2018 |
| Předmět: |
Male
Cognitive Neuroscience [SDV]Life Sciences [q-bio] [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Neurogenesis Population Olfaction Optogenetics Biology optogenetic perceptual learning 050105 experimental psychology Discrimination Learning 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Perceptual learning medicine Animals 0501 psychology and cognitive sciences [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] 10. No inequality education Neurons education.field_of_study [SCCO.NEUR]Cognitive science/Neuroscience 05 social sciences Granule cell Olfactory Perception Olfactory Bulb structural plasticity Olfactory bulb adult neurogenesis Mice Inbred C57BL medicine.anatomical_structure Odor Odorants [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neuroscience 030217 neurology & neurosurgery olfaction |
| Zdroj: | Cerebral Cortex Cerebral Cortex, Oxford University Press (OUP), In press, ⟨10.1093/cercor/bhz105⟩ Cerebral Cortex, 2019, ⟨10.1093/cercor/bhz105⟩ Cerebral Cortex, Oxford University Press (OUP), 2019, ⟨10.1093/cercor/bhz105⟩ Cerebral Cortex, Oxford University Press (OUP), 2019, 00, pp.1-16 HAL Cerebral Cortex, In press, ⟨10.1093/cercor/bhz105⟩ |
| ISSN: | 1460-2199 1047-3211 |
| Popis: | International audience; Olfactory perceptual learning is defined as an improvement in the discrimination of perceptually close odorants after passive exposure to these odorants. In mice, simple olfactory perceptual learning involving the discrimination of two odorants depends on an increased number of adult-born neurons in the olfactory bulb, which refines the bulbar output. However, the olfactory environment is complex raising the question of the adjustment of the bulbar network to multiple discrimination challenges. Perceptual learning of one to six pairs of similar odorants led to discrimination of all learned odor pairs. Increasing complexity did not increase adult-born neuron survival but enhanced the number of adult-born neurons responding to learned odorants and their spine density. Moreover, only complex learning induced morphological changes in neurons of the granule cell layer born during the first day of life (P0). Selective optogenetic inactivation of either population confirmed functional involvement of adult-born neurons regardless of the enrichment complexity while preexisting neurons were required for complex discrimination only. |
| Databáze: | OpenAIRE |
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