A stereotaxic atlas of the grey lesser mouse lemur brain (Microcebus murinus)
| Autor: | Noëlle Bons, Nadine Mestre-Francés, V. Barbié, S. Silhol, Denise Albe-Fessard |
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| Přispěvatelé: | Microbiologie et Pathologie Cellulaire Infectieuse, Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 1998 |
| Předmět: |
Microcebus murinus
[SDV]Life Sciences [q-bio] Lemuroidea Prosimian Specimen Handling Stereotaxic Techniques 03 medical and health sciences symbols.namesake 0302 clinical medicine Computer analysis biology.animal Medical Illustration Animals Primate Anatomy Artistic 030304 developmental biology 0303 health sciences biology Mouse lemur General Neuroscience Brain Anatomy biology.organism_classification Stereotaxic atlas Nissl body symbols [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Cheirogaleidae 030217 neurology & neurosurgery |
| Zdroj: | Brain Research Bulletin Brain Research Bulletin, Elsevier, 1998, 46 (1-2), pp.1-173 |
| ISSN: | 0361-9230 |
| Popis: | International audience; In response to the growing interest in the prosimian Microcebus murinus for studies on cerebral aging, the stereotaxic atlas of its brain was carried out in view of further anatomical, biochemical, electrophysiological, and behavioral investigations as well as for therapeutic experiments. This primate, which could be a valuable model for neuroscientific studies in various domains, presents numerous physiological advantages (e.g., size, cost, and ability to breed) compared to rodents, which can be used as nonprimate models, and simians. The atlas, valid for adult microcebes of every age and both sexes, consists of 54 frontal plates and 28 sagittal plates. For the establishment of stereotaxic coordinates and for drawings and photographs, 10 adult specimens of Microcebus murinus were used. The brains were frozen, cut into sections of 50 microm thickness, every fourth section being stained with Nissl. First, sections were projected and the outlines of the different structures, nuclei, and fibers were drawn. Then, the accuracy of the analysis was improved by detailed observation directly by microscope and also by computer analysis. Finally, the photographs of the sections were scanned and processed using the software Photoshop and Illustrator. For testing coordinates, several verifications were made. Experiments on lesions and injections of different substances were carried out in specific regions of the brain and brains implanted with needles were fixed in formol and embedded in paraffin wax. |
| Databáze: | OpenAIRE |
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