Prevalence of IgE against neuromuscular blocking agents in hairdressers and bakers
| Autor: | S. Dong, D. Acouetey, Paul-Michel Mertes, Jean-Louis Guéant, Rosa-Maria Guéant-Rodriguez, Miguel Blanca, T. Rémen, D. Zmirou-Navier |
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| Přispěvatelé: | Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Risque cardiovasculaire, rigidité-fibrose et hypercoagulabilité (RCV), Université Henri Poincaré - Nancy 1 (UHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), École des Hautes Études en Santé Publique [EHESP] (EHESP), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), UL, NGERE |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Allergy
[SDV]Life Sciences [q-bio] Immunology Hairdresser Cosmetics Immunoglobulin E Toxicology Anaesthesia 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Immunology and Allergy Ammonium Risk factor Sensitization Pholcodine biology business.industry Rh quaternary ammonium ion complex Radioimmunoassay Environmental exposure medicine.disease 3. Good health [SDV] Life Sciences [q-bio] medicine.anatomical_structure 030228 respiratory system chemistry Neuromuscular blocking agents biology.protein IgE business Baker/pastry make medicine.drug |
| Zdroj: | Clinical and Experimental Allergy Clinical and Experimental Allergy, Wiley, 2013, 43 (11), pp.1256-1262. ⟨10.1111/cea.12189⟩ |
| ISSN: | 0954-7894 1365-2222 |
| DOI: | 10.1111/cea.12189⟩ |
| Popis: | International audience; BackgroundAllergic IgE-mediated reactions to neuromuscular blocking agents (NMBAs) are the main cause of immediate hypersensitivity reactions in anaesthesia; their predominant occurrence in the absence of previous exposure to NMBAs suggests a risk related to environmental exposure.ObjectiveTo investigate the prevalence of specific IgE to quaternary ammonium ions in two populations professionally exposed to quaternary ammonium compounds, in the north-eastern France.MethodsThe study had a retrospective follow-up design whereby apprentices were assessed after their 2-year training period as apprentices. The professionally exposed hairdresser populations (n = 128) were compared with baker/pastry makers (n = 108) and ‘non-exposed’ matched control subjects (n = 379).ResultsWe observed a 4.6-fold higher frequency of positive IgE against quaternary ammonium ions in hairdressers (HD), compared with baker/pastry makers (BP) and control (C) groups. The competitive inhibition of quaternary ammonium Sepharose radioimmunoassay (QAS-IgE RIA) with succinylcholine was significantly higher in HD, compared with BP and C groups, with inhibition percentage of 66.2 ± 7.4, 39.7 ± 6.0 and 43.8 ± 9.9, respectively (P < 0.001). The specific IgE against quaternary ammonium ions recognized also two compounds widely used by hairdressers, benzalkonium chloride and polyquaternium-10, in competitive inhibition of IgE RIA. When considering the whole study population, hairdresser professional exposure and total IgE > 100 kU/L were the two significant predictors of IgE-sensitization against quaternary ammonium ions in the multivariate analysis of a model that included age, sex, professional exposure, increased concentration of total IgE (IgE > 100 kU/L) and positive IgE against prevalent allergens (Phadiatop®; P = 0.019 and P = 0.001, respectively).Conclusion and Clinical RelevanceThe exposure to hairdressing professional occupational factors increases IgE-sensitization to NMBAs and quaternary ammonium ion compounds used in hairdressing. Besides the pholcodine hypothesis, our study suggests that repetitive exposure to quaternary ammonium compounds used in hairdressing is a risk factor for NMBAs sensitization. |
| Databáze: | OpenAIRE |
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