Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients

Autor: Linda Klimešová, Veronika Dvořáková, Jitka Řehořová, Vendula Bartáková, Katarína Kianičková, Denisa Malúšková, Jan Svojanovský, Jindřich Olšovský, Kateřina Kaňková, Jana Bělobrádková
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Cardiovascular event
medicine.medical_specialty
Pathology
Time Factors
Article Subject
Endocrinology
Diabetes and Metabolism
Renal function
030209 endocrinology & metabolism
Kaplan-Meier Estimate
Disease
030204 cardiovascular system & hematology
Kidney
RESTING HEART RATE
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Heart Rate
Predictive Value of Tests
Risk Factors
Internal medicine
Humans
Medicine
Diabetic Nephropathies
Cumulative incidence
Prospective Studies
Stage (cooking)
Aged
Czech Republic
Proteinuria
lcsh:RC648-665
business.industry
Middle Aged
Increased risk
Diabetes Mellitus
Type 2
Cardiovascular Diseases
Disease Progression
Cardiology
Female
medicine.symptom
business
Glomerular Filtration Rate
Research Article
Zdroj: Journal of Diabetes Research, Vol 2016 (2016)
Journal of Diabetes Research
ISSN: 2314-6753
2314-6745
Popis: Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes in T2DM patients. A total of 421 T2DM patients with variable baseline stage of diabetic kidney disease (DKD) were prospectively followed. A history of the cardiovascular disease was present in 81 (19.2%) patients at baseline, and DKD (glomerular filtration rate < 60 mL/min or proteinuria) was present in 328 (77.9%) at baseline. Progressive renal decline was defined as a continuous rate of glomerular filtration rate loss ≥ 3.3% per year. Resting heart rate was not significantly higher in subjects with cardiovascular disease or DKD at baseline compared to those without. Using time-to-event analyses, significant differences in the cumulative incidence of the studied outcomes, that is, progression of DKD (and specifically progressive renal decline), major advanced cardiovascular event, and all-cause mortality, between RHR
Databáze: OpenAIRE
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