Does the method of heparinisation influence the biocompatibility of dialysis membranes?
| Autor: | J. S. Yarmolinski, A. F. Darenkov, A. P. Kochlov, E. A. Stetsyuk, V. M. Yermolenko, V. N. Sinyukhin |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_treatment Synthetic membrane Biocompatible Materials Lipid peroxidation chemistry.chemical_compound medicine Humans Infusions Intra-Arterial Platelet Cellulose Infusions Intravenous Blood Coagulation Aged Transplantation Chromatography business.industry Heparin Cuprophane Membranes Artificial Middle Aged Membrane chemistry Nephrology Beta-thromboglobulin Immunology Hemodialysis business Kidneys Artificial medicine.drug |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 6(1) |
| ISSN: | 0931-0509 |
| Popis: | The biocompatibility of cuprophanc haemodialyser membranes was investigated during two haemodialysis sessions in ten stable male chronic haemodialysis patients. In one session heparin was given intravenously, while it was given in the arterial line in the other session, using the same amount of heparin and the same filter. Biocompatibility was determined by measuring platelet and leukocyte counts, plasma beta-thromboglobulin, C3d, elastase, and lactoferrin in the arterial line at 0, 10, and 90 min of dialysis, and in the venous line at 10 and 90 min. Adequate anticoagulation was ensured by determining activated partial thromboplastin time. Platelet counts remained unchanged, whereas leukocyte counts transitorily decreased during dialysis. Plasma beta-thromboglobulin, C3d, elastase, and lactoferrin increased during haemodialysis, but no differences could be found between the two methods of heparinisation. The activation of complement, platelets, and leukocytes seemed to be independent of the mode of heparinisation. |
| Databáze: | OpenAIRE |
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