Cvt19 Is a Receptor for the Cytoplasm-to-Vacuole Targeting Pathway
| Autor: | Sidney V. Scott, Ju Guan, Maria U. Hutchins, John Kim, Daniel J. Klionsky |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Vesicle-associated membrane protein 8
Autophagy-Related Protein 8 Family Cytoplasm Saccharomyces cerevisiae Proteins Vacuole Saccharomyces cerevisiae Biology CVT pathway Aminopeptidases Article Fungal Proteins Autophagy CVT vesicle Protein Precursors Molecular Biology Cytoplasm-to-vacuole targeting Fungal protein Membrane Proteins Cell Biology Transport protein Cell biology Mutation Vacuoles Carrier Proteins Plasmids Protein Binding |
| Zdroj: | Molecular Cell. 7(6):1131-1141 |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/s1097-2765(01)00263-5 |
| Popis: | Cvt19 is specifically required for the transport of resident vacuolar hydrolases that utilize the cytoplasm-to-vacuole targeting (Cvt) pathway. Autophagy (Apg) and pexophagy, processes that use the majority of the same protein components as the Cvt pathway, do not require Cvt19. Cvt19GFP is localized to punctate structures on or near the vacuole surface. Cvt19 is a peripheral membrane protein that binds to the precursor form of the Cvt cargo protein aminopeptidase I (prAPI) and travels to the vacuole with prAPI. These results suggest that Cvt19 is a receptor protein for prAPI that allows for the selective transport of this protein by both the Cvt and Apg pathways. |
| Databáze: | OpenAIRE |
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