Clinical significance of the BRAFV600E mutation in Asian patients with colorectal cancer
| Autor: | Jen Kou Lin, Jeng Kai Jiang, Shung Haur Yang, Shih Ching Chang, Hou Hsuan Cheng, Wei Shone Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Proto-Oncogene Proteins B-raf medicine.medical_specialty Lymphovascular invasion Colorectal cancer 03 medical and health sciences 0302 clinical medicine Carcinoembryonic antigen Internal medicine medicine Humans Clinical significance Aged Neoplasm Staging Retrospective Studies biology Proportional hazards model business.industry Medical record Gastroenterology Hepatology Middle Aged medicine.disease Prognosis 030104 developmental biology 030220 oncology & carcinogenesis Mutation (genetic algorithm) Mutation biology.protein Female Neoplasm Recurrence Local business Colorectal Neoplasms |
| Zdroj: | International journal of colorectal disease. 33(9) |
| ISSN: | 1432-1262 |
| Popis: | To investigate the clinicopathological features and prognostic significance of the BRAFV600E mutation in Asian patients with colorectal cancer. We retrospectively reviewed the medical records of 1969 patients with colorectal cancer admitted to Taipei Veterans General Hospital for surgical treatment between 2000 and 2013. The measured endpoint was overall survival after surgery. The prognostic value of the BRAFV600E mutation was analyzed using the log-rank test and Cox regression analysis. The BRAFV600E mutation was detected in 106 (5.4%) patients and associated with female gender, abnormal cancer antigen (CA)19-9 at diagnosis, microsatellite status, right-sided primary tumors, mucinous histology, poor differentiation, and lymphovascular invasion. Metastatic patterns were more common in non-regional lymph node metastasis (20.8 vs. 7.4%, p = 0.06) and peritoneal seeding (41. vs. 21.2%, p = 0.04). Mutations were not prognostic in the overall survival of the entire study group but only in specific patients: age |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink