Autor: |
David B. Shackelford, Steven M. Dubinett, Tonya C. Walser, Michael C. Fishbein, David B. Stout, Clara Magyar, Sarah A. Simko, Atsuko Seki, Evan Abt, Robert McMickle, Milica Momcilovic |
Rok vydání: |
2023 |
DOI: |
10.1158/0008-5472.22411434.v1 |
Popis: |
Treatment of LKB1 mutant and LKB1 wildtype NSCLC lines with phenformin, MLN0128 or combination leads to loss of cellular ATP (S1); Metabolite analysis of NSCLC human cell line expressing dox inducible 4E-BP1 4Ala protein and control vector (S2); Biomarker analysis of normal lung tissue in response to drug treatments (S3); Treatment of Kluc mice with phenformin, MLN0128 or combination does not result in therapeutic benefit (S4); Tumor burden does not decrease in response to phenformin, MLN0128 or combination therapy in Kluc mice (S5); Biomarker analysis in tumors treated with phenformin, MLN0128 or combination (S6); Biomarker analysis of mouse tumors lysates, human NSCLC cell lines and mouse embryonic fibroblasts (S7). |
Databáze: |
OpenAIRE |
Externí odkaz: |
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