Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sldmice
| Autor: | Thomas P. Johnston, Daniel J. Stechschulte, Ossama Tawfik, Kottarappat N. Dileepan, Yuai Li |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Arteriosclerosis Immunology Aorta Thoracic Granulocyte Biology Granulopoiesis Leukocyte Count Mice chemistry.chemical_compound Internal medicine medicine.artery lcsh:Pathology medicine Animals Thoracic aorta Mast Cells Triglycerides Hypertriglyceridemia Triglyceride Monocyte Stem cell factor deficiency Cell Biology medicine.disease Mice Mutant Strains Mice Inbred C57BL Aortic intima Intima media thickness High-fat diet medicine.anatomical_structure Endocrinology Leukopoiesis chemistry Mast cell deficiency Female lcsh:RB1-214 Granulocytes Research Article |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 13, Iss 5-6, Pp 335-341 (2004) |
| ISSN: | 1466-1861 0962-9351 |
| DOI: | 10.1080/09629350400008794 |
| Popis: | STUDIES were carried out to evaluate the impact of a high-fat dietary regimen on aortic wall thickness, peripheral blood leukocyte profile, and plasma cholesterol and triglyceride levels in the mast cell-deficient Sl/Sldmouse. The results demonstrated that the mean aortic wall thickness of Sl/Sldmice was significantly higher than their normal littermates, and were increased in both genotypes after a 17-day high-fat regimen. In comparison with normal littermates, Sl/Sldgenotypes had elevated levels of plasma triglycerides with normal levels of plasma cholesterol, and the high-fat diet markedly lowered the triglyceride levels. Total peripheral blood leukocytes, the monocyte and granulocyte counts, and hemoglobin levels were significantly lower in Sl/Sldmice, although the number of lymphocytes, eosinophils and basophils were the same in both genotypes. Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sldmice. |
| Databáze: | OpenAIRE |
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