Metabolic Slowing Vanished 5 Years After Sleeve Gastrectomy in Patients With Obesity and Prediabetes/Diabetes
| Autor: | Silvia Bettini, Gabriella Milan, Francesca Favaretto, Roberto Fabris, Chiara Dal Prà, Giulia Quinto, Chiara Cosma, Roberto Vettor, Luca Busetto |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Endocrinology Diabetes and Metabolism Clinical Biochemistry prediabetes Biochemistry Metabolic adaptation Body Mass Index Prediabetic State Endocrinology Gastrectomy Weight Loss Humans Obesity Nijmegen Breakage Syndrome diabetes obesity resting energy expenditure sleeve gastrectomy Biochemistry (medical) Middle Aged Obesity Morbid Treatment Outcome Diabetes Mellitus Type 2 Female Laparoscopy |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 107(9) |
| ISSN: | 1945-7197 |
| Popis: | Background Resting energy expenditure (REE) decreases after weight loss more than expected according to body composition changes. Metabolic adaptation (MA) or metabolic slowing represents the difference between measured (m) and predicted (p) REE, and it is not clear whether it persists in the long-term. The aim of this study is to evaluate MA occurring 1 year (V1) and 5 years (V5) after laparoscopic sleeve gastrectomy (LSG) in patients with obesity and normal glucose tolerance, prediabetes (preDM) and type 2 diabetes (T2DM). Methods We reassessed 37 patients (14 males/23 females) of 44.8 ± 10 years old, since they registered all the biochemical, body composition, and REE assessments at baseline (V0), V1, and V5. Physical activity (PA) was assessed by interview and questionnaire. Results Patients displayed a percentage of weight loss of 31.5 ± 7.4% at V1 and a weight regain of 8.9 ± 7.5% at V5. Comparing V1 and V5, fat mass showed a slight increase (P = 0.011), while free fat mass remained unchanged (P = 0.304). PA improved at V1 (P Conclusion Our results suggested that only patients with preDM and T2DM displayed MA at V1, which vanished 5 years after LSG. Patients who practiced more PA prevent MA after surgery-induced wight loss. |
| Databáze: | OpenAIRE |
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