Association between urine pH and risk of contrast-associated acute kidney injury among patients after emergency percutaneous coronary intervention: a V-shape relationship?
| Autor: | Kaiyang Lin, Sicheng Zhang, Zhebin You, Chen He, Sun-Ying Wang, Haoming He, Hanchuan Chen, Yansong Guo, Xi′nan Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Physiology 030232 urology & nephrology Renal function Emergency percutaneous coronary intervention Contrast Media Urine 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Percutaneous Coronary Intervention Risk Factors Physiology (medical) Internal medicine Medicine Humans Prospective Studies Perioperative Period Aged Creatinine business.industry Acute kidney injury Odds ratio Perioperative Acute Kidney Injury Hydrogen-Ion Concentration Middle Aged medicine.disease Survival Rate Contrast-associated acute kidney injury chemistry Conventional PCI Original Article Female Urine pH Emergencies business Glomerular Filtration Rate |
| Zdroj: | Clinical and Experimental Nephrology |
| ISSN: | 1437-7799 1342-1751 |
| Popis: | Aim We investigated whether perioperative urine pH was associated with contrast-associated acute kidney injury (CA-AKI) in patients undergoing emergency percutaneous coronary intervention (PCI). Methods The study enrolled 1109 consecutive patients undergoing emergency PCI. Patients were divided into three groups based on perioperative urine pH (5.0–6.0, 6.5– 7.0, 7.5–8.5). The primary endpoint was the development of CA-AKI, defined as an absolute increase ≥ 0.3 mg/dL or a relative increase ≥ 50% from baseline serum creatinine within 48 h after contrast medium exposure. Results Overall, 181 patients (16.3%) developed contrast-associated acute kidney injury. The incidences of CA-AKI in patients with urine pH 5.0–6.0, 6.5–7.0, and 7.5–8.5 were 19.7%, 9.8%, and 23.3%, respectively. After adjustment for potential confounding factors, perioperative urine pH 5.0–6.0 and 7.5–8.5 remained independently associated with CA-AKI [odds ratio (OR)1.86, 95% confidence interval (CI) 1.25–2.82, P = 0.003; OR 2.70, 95% CI 1.5–4.68, P 2) (HR 5.587, 95% CI 1.178–30.599 vs. HR 2.487, 95% CI 1.331–4.579; overall interaction P Conclusion The urine pH and CA-AKI may underlie the V-shape relationship. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink