Preemptive leucovorin administration minimizes pralatrexate toxicity without sacrificing efficacy
| Autor: | Larisa J. Geskin, Sara K. Story, Ellen Koch |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Premedication Leucovorin Gastroenterology Article chemistry.chemical_compound Mycosis Fungoides Internal medicine medicine Mucositis Humans Adverse effect Aged Skin Aged 80 and over Mycosis fungoides business.industry Lymphoma T-Cell Peripheral Pralatrexate Hematology medicine.disease Aminopterin Discontinuation Surgery Clinical trial Oncology chemistry Antifolate Folic Acid Antagonists Female Methotrexate Lymph Nodes Tomography X-Ray Computed business medicine.drug |
| Zdroj: | Leukemia & Lymphoma. 54:2448-2451 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428194.2013.779688 |
| Popis: | Balancing efficacy and safety of drugs is key for successful cancer therapy, as adverse reactions can prohibit the use of efficacious treatments. Pralatrexate (PDX) is a novel antifolate with a higher affinity for tumor cells than methotrexate, Food and Drug Administration (FDA) approved for use in relapsed and refractory peripheral T-cell lymphoma (PTCL) and transformed mycosis fungoides (T-MF). Patients with T-MF have a higher incidence of adverse events than patients with other lymphomas, necessitating a lower recommended dose of 15 mg/m(2) (vs. 30 mg/m(2) for PTCL). Dose-limiting toxicity (DLT) mucositis occurs in about 25% of patients with T-MF, but milder mucositis is observed in almost all patients with T-MF, frequently leading to therapy discontinuation despite clinical response. Leucovorin rescue is the standard of care for high-dose methotrexate therapy, but has not been studied or recommended for use with PDX. We report our clinical experience using leucovorin with PDX (30 mg/m(2)) with good clinical response and no DLTs. Prophylactic leucovorin deserves further investigation in prospective clinical trials to allow patients with cutaneous lymphomas to receive the full benefit of PDX therapy without intolerable toxicity. |
| Databáze: | OpenAIRE |
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