Chemokines and chemokine receptors during COVID-19 infection

Autor:	Azzam A. Maghazachi, Bariaa A. Khalil, Noha Mousaad Elemam
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	ARDS Chemokine TLR toll like receptor Disease Review Biochemistry CRS cytokine releasing syndrome GAGs glycosaminoglycans Pathogenesis Chemokine receptor 0302 clinical medicine NK cells natural killer cells Structural Biology Immunopathology IP-10 IFN-γ-inducible protein 10 ARDS acute respiratory disease syndrome 0303 health sciences biology MERS-CoV Middle East respiratory syndrome coronavirus NF-κB Nuclear Factor kappa-light-chain-enhancer of activated B cells AECs airway epithelial cells Computer Science Applications ECM extracellular matrix HIV human immunodeficiency virus CAP community acquired pneumonia 030220 oncology & carcinogenesis Chemokine Receptors DCs dendritic cells Chemokines TRIF TIR-domain-containing adapter-inducing interferon-β Biotechnology NETs neutrophil extracellular traps SARS-CoV severe acute respiratory syndrome coronavirus Biophysics RSV rous sarcoma virus 03 medical and health sciences BALF bronchial alveolar lavage fluid Immune system Immunity medicine Genetics IMM inflammatory monocytes and macrophages IFN interferon 030304 developmental biology ComputingMethodologies_COMPUTERGRAPHICS PBMCs peripheral blood mononuclear cells AP-1 Activator Protein 1 business.industry SARS-CoV-2 COVID-19 medicine.disease HRSV human respiratory syncytial virus PRR pattern recognition receptors Immunology biology.protein business TP248.13-248.65 IRF interferon regulatory factor
Zdroj:	Computational and Structural Biotechnology Journal Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 976-988 (2021)
ISSN:	2001-0370
Popis:	Graphical abstract Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the main cause of hyperinflammation. In the recent COVID-19 outbreak, chemokines may be the direct cause of acute respiratory disease syndrome, a major complication leading to death in about 40% of severe cases. Several clinical investigations revealed that chemokines are directly involved in the different stages of SARS-CoV-2 infection. Here, we review the role of chemokines and their receptors in COVID-19 pathogenesis to better understand the disease immunopathology which may aid in developing possible therapeutic targets for the infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a813633e01cb0494554b46fedd72c61 http://europepmc.org/articles/PMC7859556 Zobrazit plný text záznamu