Palliation by Intratumoral Infiltration with Natural Interferon-beta
| Autor: | A. Chrissafidou, S. Linden-Lammering, M. Malek, G. Lammering, J.H. Hartlapp, E. Musch |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Analgesic Injections Intralesional Drug Administration Schedule Malignant disease Neoplasms Internal medicine medicine Humans Tumor growth Chemotherapy Dose-Response Relationship Drug Tumor size Interferon beta business.industry Palliative Care Interferon-beta Hematology Middle Aged Neoplastic Cells Circulating medicine.disease Surgery Survival Rate Palliative Therapy Lymphatic Metastasis Quality of Life Female business Infiltration (medical) Follow-Up Studies |
| Zdroj: | Oncology Research and Treatment. 24:362-366 |
| ISSN: | 2296-5262 2296-5270 |
| Popis: | Background: Curative approaches to tumor therapy have achieved greater importance through new developments such as cytostatic agents and their combination with other therapy concepts, but for the majority of tumor patients only palliative therapy is possible. Size or location of tumor manifestations can result in severe discomfort for patients, in some cases even in a reduction of functionality. Patients and Methods: For the purpose of this study, a total of 55 patients with a variety of advanced malignant diseases nonresponding or progressive under radio- and/or chemotherapy were treated by intratumoral injection of natural human fibroblast interferon (nIFN-β). nIFN-β was administered intralesionally 3 times per week for at least 4 weeks at doses of 2–8 MIU, depending on tumor size. Local tumor response was observed over a median follow-up period of 18 weeks. Results: In 37 patients (67%) a complete or partial remission of the local tumor manifestation was achieved. Survival times of these patients were improved compared with those of patients without local tumor remission. 16 patients without significant change of tumor volume benefited from the palliative (extensive analgesic) effect of the nIFN-β therapy. During treatment, none of the patients showed a progression of the locally treated tumor, even when the basic malignant disease progressed. The side effects of the nIFN-β therapy were tolerable, and no patient discontinued therapy. Conclusion: From these observations, intralesional nIFN-β therapy of malignant tumors appears to be a useful palliative addition to radio- and/or chemotherapy with the aim of local control of tumor growth. |
| Databáze: | OpenAIRE |
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