Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response
| Autor: | Lilian Rego de Carvalho, Orlando Garcia Ribeiro, Aline Marques dos Santos, Andrea Borrego, Nancy Starobinas, Olga M. Ibañez, Giacomo Manenti, Marcelo De Franco, José Ricardo Jensen, Wafa Hanna Koury Cabrera, Tommaso A. Dragani |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Carcinoma Hepatocellular Article Subject Carcinogenesis Genetic Linkage Immunology Population Interleukin-1beta Quantitative Trait Loci Biology Quantitative trait locus Transcriptome 03 medical and health sciences Mice 0302 clinical medicine Genetic linkage Genetic predisposition medicine Animals Outbred Strains Immunology and Allergy Animals Genetic Predisposition to Disease Inbreeding Allele education Alleles 030304 developmental biology Inflammation 0303 health sciences education.field_of_study Interleukin-6 Liver Neoplasms General Medicine medicine.disease Phenotype Mice Inbred C57BL Disease Models Animal 030220 oncology & carcinogenesis Hepatocellular carcinoma Tumor Necrosis Factors Cancer research lcsh:RC581-607 Research Article |
| Zdroj: | Journal of Immunology Research Journal of Immunology Research, Vol 2019 (2019) |
| ISSN: | 2314-7156 2314-8861 |
| Popis: | AIRmax and AIRmin mouse strains phenotypically selected for high and low acute inflammatory responsiveness (AIR) are, respectively, susceptible or resistant to developing hepatocellular carcinoma (HCC) induced by the chemical carcinogens urethane and diethylnitrosamine (DEN). Early production of TNF-α, IL-1β, and IL-6 in the liver after DEN treatment correlated with tumor development in AIRmax mice. Transcriptome analysis of livers from untreated AIRmax and AIRmin mice showed specific gene expression profiles in each line, which might play a role in their differential susceptibility to HCC. Linkage analysis with SNP markers in F2 (AIRmax×AIRmin) intercross mice revealed two quantitative trait loci (QTL) in chromosomes 2 and 9, which are significantly associated with the number and progression of urethane-induced liver tumors. An independent linkage analysis with an intercross population from A/J and C57BL/6J inbred mice mapped regions in chromosomes 1 and 7 associated with the progression of urethane-induced liver tumors, evidencing the heterogeneity of HCC genetic control. |
| Databáze: | OpenAIRE |
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