Sporadic non-functioning pancreatic neuroendocrine tumours: multicentre analysis
| Autor: | Laura Alberici, Carlo Ingaldi, Luca Landoni, Claudio Ricci, Martina Fontana, Stefano Partelli, Riccardo Casadei, Claudio Bassi, D Campana, Domenico Tamburrino, Massimo Falconi, Valentina Andreasi, G. Deiro, Francesca Muffatti, Chiara Nessi, Maria Rinzivillo, F Panzuto |
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| Přispěvatelé: | Ricci, C, Partelli, S, Landoni, L, Rinzivillo, M, Ingaldi, C, Andreasi, V, Nessi, C, Muffatti, F, Fontana, M, Tamburrino, D, Deiro, G, Alberici, L, Campana, D, Panzuto, F, Bassi, C, Falconi, M, Casadei, R, Ricci C., Partelli S., Landoni L., Rinzivillo M., Ingaldi C., Andreasi V., Nessi C., Muffatti F., Fontana M., Tamburrino D., Deiro G., Alberici L., Campana D., Panzuto F., Bassi C., Falconi M., Casadei R. |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty 030209 endocrinology & metabolism Neuroendocrine tumors Gastroenterology Follow-Up Studie pancreatic endocrine tumors surgery prognosis 03 medical and health sciences 0302 clinical medicine Pancreatectomy Retrospective Studie Internal medicine Risk of mortality medicine Humans Stage (cooking) Survival analysis Neoplasm Staging Retrospective Studies Relative survival business.industry Hazard ratio Pancreatic Neoplasm medicine.disease Pancreatic Neoplasms Survival Rate medicine.anatomical_structure Italy 030220 oncology & carcinogenesis Cohort Surgery Pancreas business Human Follow-Up Studies |
| Popis: | Background Outcomes after surgery for sporadic pancreatic neuroendocrine neoplasms (Pan-NENs) were evaluated. Methods This multicentre study included patients who underwent radical pancreatic resection for sporadic non-functioning Pan-NENs. In survival analysis, the risk of mortality in this cohort was analysed in relation to that of the matched healthy Italian population. Relative survival (RS) was calculated as the rate between observed and expected survival. Factors related to RS were investigated using multivariable modelling. Results Among 964 patients who had pancreatic resection for sporadic non-functioning Pan-NENs, the overall RS rate was 91.8 (95 per cent c.i. 81.5 to 96.5) per cent. 2019 WHO grade (hazard ratio (HR) 5.75 (s.e. 4.63); P = 0.030) and European Neuroendocrine Tumour Society (ENETS) TNM stage (6.73 (3.61); P Conclusion A surgical approach seems without benefit for Pan-NECs, and unnecessary for small G1 sporadic Pan-NENs. Surgery alone may be insufficient for stage III–IV and G3 Pan-NENs. |
| Databáze: | OpenAIRE |
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