Turning-ON Proteasomes
| Autor: | Farnusch Kaschani, Jan H. Krahn, Markus Kaiser |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Proteasome Endopeptidase Complex p38 mitogen-activated protein kinases Clinical Biochemistry Cell Chemie Chemical biology Biology Protein aggregation p38 Mitogen-Activated Protein Kinases 01 natural sciences Biochemistry 03 medical and health sciences Drug Discovery medicine Molecular Biology Pharmacology 010405 organic chemistry Activator (genetics) 0104 chemical sciences Cell biology Enzyme Activation 030104 developmental biology medicine.anatomical_structure Proteasome Molecular Medicine Proteasome Inhibitors Biologie |
| Zdroj: | Cell Chemical Biology. 24:653-655 |
| ISSN: | 2451-9456 |
| DOI: | 10.1016/j.chembiol.2017.06.005 |
| Popis: | While proteasome inhibitors are now well-established research tools and chemotherapeutics, proteasome activators are much less explored. In this issue of Cell Chemical Biology, in a study from the groups of Berkers and Ovaa (Leestemaker et al., 2017), a chemical screen was used to identify a p38 MAPK inhibitor as a proteasome activator. This compound furthermore enhanced clearance of protein aggregates, thereby implicating alternative chemotherapeutic options for treating neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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