Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation
| Autor: | Jiaxing Wu, Daniel Maruyama, Sima Mofakham, Samantha Schaeffer, Michal Zochowski, Sara J. Aton, Nicolette Ognjanovski |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Nerve net Science Action Potentials General Physics and Astronomy Mice Transgenic Neurotransmission Hippocampal formation Synaptic Transmission General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Interneurons Memory Neuroplasticity medicine Animals Learning CA1 Region Hippocampal Episodic memory Neuronal Plasticity Multidisciplinary biology Chemistry General Chemistry Network dynamics Electric Stimulation Mice Inbred C57BL Parvalbumins 030104 developmental biology medicine.anatomical_structure biology.protein Memory consolidation Nerve Net Erratum Neuroscience 030217 neurology & neurosurgery Parvalbumin |
| Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Activity in hippocampal area CA1 is essential for consolidating episodic memories, but it is unclear how CA1 activity patterns drive memory formation. We find that in the hours following single-trial contextual fear conditioning (CFC), fast-spiking interneurons (which typically express parvalbumin (PV)) show greater firing coherence with CA1 network oscillations. Post-CFC inhibition of PV+ interneurons blocks fear memory consolidation. This effect is associated with loss of two network changes associated with normal consolidation: (1) augmented sleep-associated delta (0.5–4 Hz), theta (4–12 Hz) and ripple (150–250 Hz) oscillations; and (2) stabilization of CA1 neurons’ functional connectivity patterns. Rhythmic activation of PV+ interneurons increases CA1 network coherence and leads to a sustained increase in the strength and stability of functional connections between neurons. Our results suggest that immediately following learning, PV+ interneurons drive CA1 oscillations and reactivation of CA1 ensembles, which directly promotes network plasticity and long-term memory formation. |
| Databáze: | OpenAIRE |
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