The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression
| Autor: | Rachel J. West, Eric J. Lambie, Andrew Y. Sun, Diane L. Church |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
endocrine system
Transcription Genetic Molecular Sequence Data Mutant Nonsense-mediated decay Locus (genetics) Biology Transient receptor potential channel Mitotic cell cycle Genetics Animals Amino Acid Sequence RNA Messenger Caenorhabditis elegans Gonads Gene Alleles Conserved Sequence Genes Helminth TRPC Cation Channels Messenger RNA Sequence Homology Amino Acid Cell Cycle fungi General Medicine Cell cycle Molecular biology Mutation Calcium Channels Sequence Alignment Cell Division |
| Zdroj: | Gene. 266:103-110 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/s0378-1119(01)00373-0 |
| Popis: | The C. elegans gon-2 gene is required for the post-embryonic mitotic cell divisions of the gonadal precursor cells. A single major transcript of approximately 6.7 kb is derived from the gon-2 locus. This mRNA encodes a protein related to the TRP family of cation channels and has a high degree of similarity to several vertebrate genes, including melastatin. Mutant alleles of gon-2 affect evolutionarily conserved amino acid residues. Northern analyses suggest that gon-2 expression is not limited to gonadal tissues. |
| Databáze: | OpenAIRE |
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