Regulation of CART mRNA in the rat nucleus accumbens via D3 dopamine receptors
| Autor: | Michael J. Kuhar, Aleksandra Vicentic, Douglas C. Jones, Gillian Hue, David B. Rye, Richard G. Hunter |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Cart Agonist medicine.medical_specialty medicine.drug_class Nerve Tissue Proteins Pharmacology Nucleus accumbens Nucleus Accumbens Dihydrexidine Rats Sprague-Dawley Cellular and Molecular Neuroscience Quinpirole immune system diseases Dopamine Internal medicine mental disorders medicine Animals RNA Messenger Chemistry Receptors Dopamine D3 Antagonist virus diseases Rats Endocrinology nervous system Dopamine receptor Dopamine Agonists Dopamine Antagonists medicine.drug |
| Zdroj: | Neuropharmacology. 50:858-864 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/j.neuropharm.2005.12.007 |
| Popis: | A variety of studies indicate that CART in the nucleus accumbens (NAcc) is involved in the action of psychostimulants. In order to understand in more detail if and how dopamine is involved in the regulation of CART mRNA in the NAcc, the present studies of individual receptors were performed. The D1 agonist, dihydrexidine, and the D1 antagonist, SCH23,390, were administered separately and in combination to adult male rats; however, no changes were found in CART mRNA as measured by in situ hybridization. The D2/3 agonist, quinpirole, was administered either separately or in combination with the D2 selective antagonist, L741,626, or the D3 selective antagonist, GR103,691. Quinpirole produced a decrease in CART mRNA of up to 43%. This effect was blocked by pretreatment with the D3 antagonist GR103, 691, but not by the D2 antagonist, L741,626. CART peptide levels showed a similar decrement after acute quinpirole. CART mRNA levels in the NAcc of D3 mutant mice were found to be higher than that in wild-type animals, but treating the mutants with quinpirole failed to produce a decrease in CART expression like that observed in wild-type rodents. These findings demonstrate that CART is regulated by dopamine in the NAcc, at least partly by D3 dopamine receptors. |
| Databáze: | OpenAIRE |
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