Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study

Autor: Rosa María García-Hernández, Rafael Ogaz-González, Ángel Mérida-Ortega, Mariano E. Cebrián, Lizbeth López-Carrillo, Stephen J. Rothenberg, César Hernández-Alcaraz, Luisa Torres-Sánchez, Lourdes Schnaas
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Insecticides
Health
Toxicology and Mutagenesis
Population
Physiology
Mothers
3rd trimester
Bayley Scales of Infant Development
DDT
Cohort Studies
03 medical and health sciences
lcsh:RC963-969
Child Development
Pregnancy
Medicine
Ingestion
Humans
Prospective cohort study
education
Maternal-Fetal Exchange
Mexico
chemistry.chemical_classification
0303 health sciences
education.field_of_study
business.industry
Research
Child neurodevelopment
lcsh:Public aspects of medicine
Public Health
Environmental and Occupational Health
Infant
Newborn
030311 toxicology
Infant
lcsh:RA1-1270
medicine.disease
Diet
chemistry
Maternal Exposure
Child
Preschool
Fatty Acids
Unsaturated
lcsh:Industrial medicine. Industrial hygiene
Environmental Pollutants
Female
Polyunsaturated fatty acids
business
Polyunsaturated fatty acid
Cohort study
Zdroj: Environmental Health, Vol 18, Iss 1, Pp 1-7 (2019)
Environmental Health
Popis: Background Child neurodevelopment has been positively linked to maternal intake of polyunsaturated fatty acids (PUFAs) during pregnancy; however, it is unknown if that relationship persists among populations exposed to environmental neurotoxicants. Objective The aim of this work was to assess whether maternal dietary intake of PUFAs during pregnancy is positively associated with child neurodevelopment, whose mothers were environmentally exposed to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). Methods A prospective cohort study with 276 mother–child pairs was performed in Mexico. Neurodevelopment was assessed by Bayley Scales II from children age 1 to 30 months. Dietary PUFAs intake was estimated by Food Frequency Questionnaire at 1st and 3rd trimester of pregnancy. DDE (1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene, the main metabolite of DDT) maternal serum levels were determined by electron capture gas chromatography. Longitudinal multivariate linear mixed-effects analysis, which combines mental (MDI) and motor (PDI) Bayley scales in a single model, were performed. Results Our results show that in a sample environmentally exposed to DDT, maternal ingestion of DPA during the first trimester of pregnancy was positively associated with MDI (β = 0.10, 95% CI 0.02, 0.18) in children from 1 to 30 months. Likewise, our results suggest that dietary ALA may be also related to MDI. Conclusion DPA may benefit neurodevelopment even in populations exposed to DDT. Our results strengthen the importance of PUFAs intake during the prenatal period. Electronic supplementary material The online version of this article (10.1186/s12940-019-0456-8) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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