Synthesis and Characterization of α-ZrP@CHI Drug Deliver System
| Autor: | Haiquan Su, Xuechuan Gao, Zhao Li, Shiyong Yu, Renfei Zhang, Zhibing Tan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Materials science media_common.quotation_subject Biomedical Engineering chemistry.chemical_element Bioengineering Nanocapsules Diffusion Chitosan 03 medical and health sciences chemistry.chemical_compound Materials Testing General Materials Science Lamellar structure media_common Zirconium Nanocomposite General Chemistry Condensed Matter Physics Anti-Bacterial Agents Gentamicin Sulfate 030104 developmental biology chemistry Chemical engineering Delayed-Action Preparations Drug release Gentamicins |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 16:3628-3631 |
| ISSN: | 1533-4880 |
| Popis: | This paper described the controlled synthesis and release properties of a new kind of multifunctional drug-release system which was prepared by encapsulation of zirconium bis-(monohydrogen orthophosphate) monohydrate (α-ZrP) with chitosan (CHI). As obtained the α-ZrP@CHI nanocomposites were found to possess the structural features of both α-ZrP and CHI. The release properties of the α-ZrP@CHI nanocomposites were evaluated using Gentamicin sulfate as the model drug. And α-ZrP@CHI composites showed a prolonged drug release time compared with α-ZrP, which can be attributed to the unique lamellar structure and the encapsulation with CHI. The controlled synthesis of α-ZrP@CHI nanocomposite thus provided a new opportunity for future development of delivery vehicles. |
| Databáze: | OpenAIRE |
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