Role of adrenergic nerves in blood-induced cerebral vasospasm
| Autor: | J D Irvin, P E Vinall, F A Simeone, J L Alderman |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Serotonin Sympathetic Nervous System Adrenergic receptor Cerebral arteries Norepinephrine (medication) Hydroxydopamines Norepinephrine Cerebral vasospasm Phentolamine medicine.artery Internal medicine medicine Animals Advanced and Specialized Nursing Denervation Dose-Response Relationship Drug business.industry Desipramine Vasospasm Cerebral Arteries Receptors Adrenergic alpha medicine.disease Endocrinology Blood Ischemic Attack Transient Middle cerebral artery Calcium Cattle Neurology (clinical) Cardiology and Cardiovascular Medicine business Adrenergic Fibers medicine.drug |
| Zdroj: | Stroke. 10(4) |
| ISSN: | 0039-2499 |
| Popis: | Cerebral arteries have an abundant supply of adrenergic nerve fibers which are believed to release vasoactive substances responsible for the induction of cerebral vasospasm. To assess the importance of adrenergic nerves in this phenomenon, high doses (600 microgram/ml) of 6-hydroxydopamine (6-OHDA) were used to produce in vitro chemical sympathectomy in bovine middle cerebral artery. 6-OHDA reduced catecholamine fluorescence to undectable limits. H3-norepinephrine re-uptake was reduced to 1.5% of intact controls. Arterial norepinephrine content was reduced by 92%. Contractile responses to norepinephrine, serotonin, and fresh human whole blood were modestly reduced after denervation. This reduction was probably due to alpha receptor inactivation by 6-OHDA, because after protection of the alpha receptors with phentolamine the vessel response was the same as in untreated controls. Contractions in response to aged human whole blood were not affected by denervation. The results suggest that the endogenous release of catecholamines does not play a major role in the initiation or spread of blood-induced vasospasm in large cerebral arteries. |
| Databáze: | OpenAIRE |
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