Significance of the plasma lipid profile in cases of carcinoma of cervix: a tertiary hospital based study
| Autor: | Narayanaswamy Mariyappa, Sumathi Mayagondanahalli Eshwarappa, Chandramouli Anjaneya, Kalyani Raju, Shruthi Suresh Punnayanapalya, Lee Jun Kai |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Pathology Epidemiology India Uterine Cervical Neoplasms Gastroenterology Tertiary Care Centers chemistry.chemical_compound High-density lipoprotein Internal medicine medicine Carcinoma Humans Cervix Triglycerides Aged Neoplasm Staging Cervical cancer Aged 80 and over medicine.diagnostic_test business.industry Cholesterol Cholesterol HDL Public Health Environmental and Occupational Health Case-control study Cancer Cholesterol LDL Middle Aged medicine.disease medicine.anatomical_structure Oncology chemistry Case-Control Studies Carcinoma Squamous Cell lipids (amino acids peptides and proteins) Female Neoplasm Grading business Lipid profile |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 15(8) |
| ISSN: | 2476-762X |
| Popis: | Aims: To study alterations of plasma lipid profiles in carcinoma cervix and to assess significance comparedwith controls in different histological grades and stages. Materials and Methods: Totals of 99 histopathologically diagnosed cases and 35 controls from a tertiary hospital situated in the southern part of India which caters the rural and semi-urban populations were considered for the study. Fasting blood samples were taken to analyze total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoproteins cholesterol (LDL-C), for comparison of cases, grouped according to histological grades and stages, and controls. One way ANOVA was used for multiple group comparisons and the Student’s t test (unpaired) for group wise comparisons. For all tests a ‘p’ value of 0.05 or less was considered as significant. Results: Out of 99 cases, most (n-39) were seen in the 40-49 year age group followed by 60-69 years (n-22). Serum TG significantly differed between cases and controls but without any relation to differentiation grade. The lipid profile parameters in various grades of cervical cancer were not statistically significant. Statistically significant increase of TC and LDL-C values was observed with increase in stage of the disease. Conclusions: The study showed TG is elevated in cervical cancer, and that TC and LDL-C are proportional to the spread of cancer as it increases from stage I to stage IV. An in-depth study of molecular changes in lipid metabolism in cervical cancer patients, enzymes/ genes responsible and alterations in LDL receptors is necessary to provide information to decide whether the lipid profile has any diagnostic/prognostic role in cervical cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|