Turner's syndrome with concomitant hypopituitarism: case report
| Autor: | Zoe Efstathiadou, Agathocles Tsatsoulis |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics Gonad Gonadal dysgenesis Turner Syndrome Hypopituitarism Biology Hypopituitarism/*complications Hypothalamic disease Growth hormone deficiency Hypogonadotropic hypogonadism Turner syndrome Thyroxine/therapeutic use medicine Humans Turner Syndrome/*complications/*diagnosis/drug therapy/pathology Progestins/therapeutic use Gynecology Bone Development Rehabilitation Obstetrics and Gynecology Estrogens medicine.disease Body Height Thyroxine medicine.anatomical_structure Reproductive Medicine Estrogens/therapeutic use Drug Therapy Combination Female Progestins Hypogonadotrophic hypogonadism |
| Zdroj: | Human reproduction (Oxford, England). 15(11) |
| ISSN: | 0268-1161 |
| Popis: | The unique case of a young woman with concomitant pituitary insufficiency and gonadal dysgenesis due to Turner's syndrome is described. At the age of 17 years, when first examined elsewhere, this patient was prepubertal and short and a diagnosis of growth hormone deficiency was made. One year later, while on growth hormone (GH) substitution, thyrotrophin deficiency and hypogonadotrophic hypogonadism were confirmed and thyroxine and sex steroid substitution therapy was initiated. Upon evaluation in our clinic, at the age of 30 years, the low final height achieved with the GH substitution therapy, a number of clinical characteristics and the absence of ovarian tissue on ultrasound led to examination of the patient's karyotype, which revealed concurrent gonadal dysgenesis due to Turner's syndrome. This case illustrates that the co-existence of primary and secondary hypogonadism may obscure and delay the diagnosis of Turner's syndrome, a diagnosis which alters the counselling of the patient from the reproductive perspective. Hum Reprod |
| Databáze: | OpenAIRE |
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