The effect of β‐amyloid positivity on cerebral metabolism in cognitively normal seniors
Autor: | Monica Zdanukiewicz, Andrea Bozoki, David C. Zhu |
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Rok vydání: | 2016 |
Předmět: |
Male
0301 basic medicine Apolipoprotein E Aging Amyloid Pathology medicine.medical_specialty Epidemiology Apolipoprotein E4 Hippocampus Standardized uptake value 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience Neuroimaging Fluorodeoxyglucose F18 medicine Humans Aged Cerebral Cortex medicine.diagnostic_test Health Policy Entorhinal cortex Psychiatry and Mental health Glucose 030104 developmental biology medicine.anatomical_structure Positron emission tomography Cerebral cortex Positron-Emission Tomography Posterior cingulate Female Neurology (clinical) Radiopharmaceuticals Geriatrics and Gerontology Psychology 030217 neurology & neurosurgery |
Zdroj: | Alzheimer's & Dementia. 12:1250-1258 |
ISSN: | 1552-5279 1552-5260 |
Popis: | Introduction We evaluated the effect of cerebral amyloid-β (Aβ) deposition in cognitively normal (CN) seniors on regional metabolism of specific brain regions known to be affected by p-tau deposition. Methods Fluorodeoxyglucose positron emission tomography (FDG-PET), volumetric magnetic resonance imaging scans, and global amyloid standardized uptake value ratios (SUVr) were obtained for 210 CNs from the Alzheimer's Disease Neuroimaging Initiative-2 ( ADNI2 ). Region of interest (ROI) extraction was used to obtain functional SUVr from six bilateral ROIs: amygdala (AM), entorhinal cortex (EC), hippocampus, lateral orbitofrontal, posterior cingulate (PC), and middle temporal gyrus. Every metabolic SUVr set was averaged and analyzed against the corresponding subject's amyloid SUVr. Correlation analyses were conducted on the full group and between APOE e4-positive and APOE e4-negative subgroups. Results The APOE e4+ group exhibited significantly higher metabolism in the EC (r = 0.270, P = .038) and AM (r = 0.267, P = .041). When a significance of the difference test was conducted between the APOE e4+ and APOE e4-groups, these same regions remained significant: P = .012 and P = .016, respectively. By contrast, the APOE e4 group displayed only the conventionally expected result of reduced regional metabolism in the PC (r = −0.161, P = .048), with higher Aβ load. Conclusions The effect of amyloid positivity on brain metabolism is regionally specific, and APOE e4 status substantially modulates regional glucose uptake in these regions. The APOE e4 allele may cause earlier emergence of clinical symptoms in AD via a mechanism that influences regional metabolic demand in specifically those regions where p-tau deposition is known to occur earliest. |
Databáze: | OpenAIRE |
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