High innate production of interleukin-10 and tumor necrosis factor-α contributes to susceptibility for non-paraneoplastic Lambert–Eaton myasthenic syndrome
| Autor: | Dirk-Jan Stoeken, Jan J.G.M. Verschuuren, Tom W J Huizinga, Axel R. Wintzen, Paul W. Wirtz |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Immunology Stimulation Disease Malignancy Downregulation and upregulation Immunity medicine Humans Immunology and Allergy Tumor Necrosis Factor-alpha business.industry Middle Aged medicine.disease Immunity Innate Interleukin-10 Up-Regulation Lambert-Eaton Myasthenic Syndrome Interleukin 10 Neurology Female Tumor necrosis factor alpha Disease Susceptibility Neurology (clinical) business Lambert-Eaton myasthenic syndrome |
| Zdroj: | Journal of Neuroimmunology. 140:194-197 |
| ISSN: | 0165-5728 |
| Popis: | Non-paraneoplastic Lambert-Eaton myasthenic syndrome (LEMS) is an antibody-mediated autoimmune disorder, in which genetically determined interleukin-10 (Il-10) and tumor necrosis factor-alpha (TNF-alpha) could play a role in the susceptibility for the disease. Therefore, we analyzed the production of Il-10 and TNF-alpha after whole-blood stimulation in first-degree family members of patients with LEMS without malignancy, as a measure of innate production in the patients. Thirty-six first-degree family members of 10 patients and 80 healthy controls were studied. Both Il-10 (p=0.037) and TNF-alpha (p=0.0016) production were increased in the family members, but had no relation with the severity of LEMS or HLA-B8DR3 carriership. Our findings suggest that high innate production of Il-10 and TNF-alpha is a susceptibility factor for non-paraneoplastic LEMS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect