The Potential Role of miRNAs as Predictive Biomarkers in Neurodevelopmental Disorders

Autor: Ahmad Tarmizi Che Has, Iman Imtiyaz Ahmed Juvale
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Neurology
Autism Spectrum Disorder
Impulsivity
Bioinformatics
Tourette syndrome
03 medical and health sciences
Cellular and Molecular Neuroscience
Mice
0302 clinical medicine
Neonatal Screening
Pregnancy
medicine
Attention deficit hyperactivity disorder
Animals
Humans
Neurochemistry
Zebrafish
business.industry
Infant
Newborn
Gene Expression Regulation
Developmental
Infant
Cognition
General Medicine
medicine.disease
Amniotic Fluid
Fragile X syndrome
Disease Models
Animal
MicroRNAs
030104 developmental biology
Early Diagnosis
Autism spectrum disorder
Attention Deficit Disorder with Hyperactivity
Neurodevelopmental Disorders
Fragile X Syndrome
Female
medicine.symptom
Down Syndrome
business
030217 neurology & neurosurgery
Biomarkers
Tourette Syndrome
Zdroj: Journal of molecular neuroscience : MNReferences. 71(7)
ISSN: 1559-1166
Popis: Neurodevelopmental disorders are defined as a set of abnormal brain developmental conditions marked by the early childhood onset of cognitive, behavioral, and functional deficits leading to memory and learning problems, emotional instability, and impulsivity. Autism spectrum disorder, attention-deficit/hyperactivity disorder, Tourette syndrome, fragile X syndrome, and Down's syndrome are a few known examples of neurodevelopmental disorders. Although they are relatively common in both developed and developing countries, very little is currently known about their underlying molecular mechanisms. Both genetic and environmental factors are known to increase the risk of neurodevelopmental disorders. Current diagnostic and screening tests for neurodevelopmental disorders are not reliable; hence, individuals with neurodevelopmental disorders are often diagnosed in the later stages. This negatively affects their prognosis and quality of life, prompting the need for a better diagnostic biomarker. Recent studies on microRNAs and their altered regulation in diseases have shed some light on the possible role they could play in the development of the central nervous system. This review attempts to elucidate our current understanding of the role that microRNAs play in neurodevelopmental disorders with the hope of utilizing them as potential biomarkers in the future.
Databáze: OpenAIRE
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