Endovascular catheter-delivered photodynamic therapy in an experimental response to injury model
| Autor: | Ulrich Welsch, Ronald Sroka, P. Gonschior, Alwin E. Goetz, H. A. Lehr, M. Dellian, F. Gerheuser, M. Fleuchaus, B. Höfling, T. Y. Huehns, C. Vogel-Wiens, F. Breger |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Swine Physiology medicine.medical_treatment Photo dynamic therapy Photodynamic therapy Restenosis Response to injury Physiology (medical) Angioplasty Catheterization Peripheral medicine Animals Vascular Diseases cardiovascular diseases Hyperplasia Photosensitizing Agents business.industry medicine.disease Immunohistochemistry eye diseases Surgery Femoral Artery Disease Models Animal Microscopy Electron Catheter Carotid Arteries Microscopy Fluorescence Photochemotherapy Injury model Carotid Artery Injuries Cardiology and Cardiovascular Medicine business Cell Division |
| Zdroj: | Basic Research in Cardiology. 92:310-319 |
| ISSN: | 1435-1803 0300-8428 |
| DOI: | 10.1007/bf00788943 |
| Popis: | The effectiveness of local endovascular photodynamic therapy (PDT) in preventing tissue hyperplasia was evaluated in a vascular injury model.Standardized unidirectional arterial injury with a directional atherectomy catheter was performed in porcine arteries (n = 180). Animals (n = 72) were randomly allocated to unidirectional injury only (Group 1), injury followed by drug delivery of photosensitizer with a porous balloon (Group 2), or by local exposure to monochromatic light (Group 3). In Group 4, injury was followed by local drug delivery of photosensitizer and subsequent exposure to light (PDT). Up to 21 days after treatment, all experimental vessels were excised, fixed and processed for histology, immunohistochemistry and transmission electron microscopy.After vascular injury an inflammatory and myoproliferative response was observed in Groups 1, 2 and 3 (mean tissue hyperplasia/media ratio 1.0 +/- 0.5 at 21 days; area tissue hyperplasia: 1.57 +/- 0.9 mm2). Proliferation in injured vascular segments (Group 1-3) reached a maximum at 7 days, with 6%. Only in Group 4, after injury followed by photodynamic therapy, was there no significant vascular response (mean tissue hyperplasia/media ratio 0.3 +/- 0.2: area tissue hyperplasia: 0.1 +/- 0.05 mm2 p0.001, proliferating cells 0.3%).Vascular response after unidirectional injury was suppressed only by endovascular photodynamic therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink