Antagonistic effects of Zingerone, a phenolic alkanone against radiation-induced cytotoxicity, genotoxicity, apoptosis and oxidative stress in Chinese hamster lung fibroblast cells growing in vitro

Autor:	B. Nageshwar Rao, B. S. Satish Rao
Rok vydání:	2010
Předmět:	Zingerone Health Toxicology and Mutagenesis Drug Evaluation Preclinical Apoptosis Biology Toxicology medicine.disease_cause Models Biological Antioxidants Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Cricetulus Phenols Cricetinae Alkanes Genetics medicine Animals Lung Cells Cultured Genetics (clinical) Cell Proliferation chemistry.chemical_classification Reactive oxygen species Guaiacol Glutathione Fibroblasts Malondialdehyde Molecular biology Comet assay Oxidative Stress Radiation Injuries Experimental chemistry Cytoprotection biology.protein Oxidative stress DNA Damage
Zdroj:	Mutagenesis. 25:577-587
ISSN:	1464-3804 0267-8357
DOI:	10.1093/mutage/geq043
Popis:	Zingerone (ZO), a dietary phenolic compound was investigated for its ability to protect against radiation-induced oxidative stress and DNA damage in Chinese hamster fibroblast cells (V79). Cells treated with optimal dose of ZO (25 μg/ml), 1 h prior radiation exposure resulted in a significant (P
Databáze:	OpenAIRE
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