New gene targets related to schizophrenia and other psychiatric disorders: enzymes, binding proteins and transport proteins involved in phospholipid and fatty acid metabolism
| Autor: | David F. Horrobin, C.N. Bennett |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Psychosis
medicine.medical_specialty Bipolar Disorder Clinical Biochemistry Phospholipid Biology Dyslexia chemistry.chemical_compound Alzheimer Disease medicine Humans Attention deficit hyperactivity disorder Bipolar disorder Psychiatry Phospholipids Genetics Depressive Disorder Fatty acid metabolism Mental Disorders Fatty Acids Brain Parkinson Disease Cell Biology medicine.disease Enzymes Transport protein Cerebrovascular Disorders chemistry Schizophrenia Signal transduction Carrier Proteins |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 60:141-167 |
| ISSN: | 0952-3278 |
| DOI: | 10.1054/plef.1999.0027 |
| Popis: | Phospholipids make up about 60% of the brain's dry weight. In spite of this, phospholipid metabolism has received relatively little attention from those seeking genetic factors involved in psychiatric and neurological disorders. However, there is now increasing evidence from many quarters that abnormal phospholipid and related fatty acid metabolism may contribute to illnesses such as schizophrenia, bipolar disorder, depression and attention deficit hyperactivity disorder. To date the possible specific proteins and genes involved have been relatively ill-defined. This paper reviews the main pathways of phospholipid metabolism, emphasizing the roles of phospholipases of the A 2 and C series in signal transduction processes. It identifies some likely protein candidates for involvement in psychiatric and neurological disorders. It also reviews the chromosomal locations of regions likely to be involved in these disorders, and relates these to the known locations of genes directly or indirectly involved in phospholipid and fatty acid metabolism. |
| Databáze: | OpenAIRE |
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