Tumour growth and immune evasion as targets for a new strategy in advanced cancer
| Autor: | Andrea Nicolini, Angelo Carpi, Giuseppe Rossi, Paola Ferrari |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cancer Research Endocrinology Diabetes and Metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Breast cancer Immune system Tumor Microenvironment medicine Humans Pathological Immune Evasion Therapeutic strategy business.industry Cancer Evasion (ethics) medicine.disease Advanced cancer 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer cell Cancer research Female Immunotherapy business |
| Zdroj: | Endocrine-Related Cancer. 25:R577-R604 |
| ISSN: | 1479-6821 1351-0088 |
| DOI: | 10.1530/erc-18-0142 |
| Popis: | It has become clearer that advanced cancer, especially advanced breast cancer, is an entirely displayed pathological system that is much more complex than previously considered. However, the direct relationship between tumour growth and immune evasion can represent a general rule governing the pathological cancer system from the initial cancer cells to when the system is entirely displayed. Accordingly, a refined pathobiological model and a novel therapeutic strategy are proposed. The novel therapeutic strategy is based on therapeutically induced conditions (undetectable tumour burden and/or a prolonged tumour ‘resting state’), which enable an efficacious immune response in advanced breast and other types of solid cancers. |
| Databáze: | OpenAIRE |
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